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What is the difference between rough ER and smooth ER?

Rough ER is studded with ribosomes and makes proteins; smooth ER lacks ribosomes and makes lipids.

Rough ER is studded with ribosomes and makes proteins; smooth ER lacks ribosomes and makes lipids. A reliable way to keep them apart is to focus on what each one is defined by, not just the similar-sounding words.

Key point

rough ER vs smooth ER

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